Argireline (Acetyl Hexapeptide-3)

Argireline is the trade name for Acetyl Hexapeptide-3, a synthetic anti-aging cosmetic peptide derived from natural proteins. It is a peptide chain made up of amino acids. Argireline has been shown in research studies to help decrease the visible effects of aging by helping to reduce the deep wrinkles and lines that occur around the forehead and eyes. As a result, a large number of cosmetics companies include Argireline in the formulation of their anti-aging products. These products include creams, lotions, serums, body milks, eye creams, gels and emulsions.

Chemically, when applied as a solution to specific areas of the face, Argireline inhibits the reactions that cause muscles to move or contract – for example when forming facial expressions such as smiling or frowning. In theory, repetitive muscle movements create lines and wrinkles and it is believed the attenuation of muscular contractions can reduce the depth of existing wrinkles and prevent the formation of new lines. Research studies have found that Argireline has been shown to produce a significant anti-aging effect. within the skin.

Acetyl Hexapeptide-3 (Argireline) inhibits the release of neurotransmitters as it interferes with the formation and stabilization of the protein complex needed for docking vesicles of acetylcholine release. In an open study often female subjects, a serum containing this peptide was applied twice a day. After 1 month, the results showed a reduction in periorbital wrinkle depth of 27%. The in vitro effect of neurotransmitter-inhibiting peptides is to inhibit the release of neurotransmitters, while the desired, in vivo, effect is to reduce facial wrinkles caused by a decrease in muscle activity.

Research tests were performed using a combination of both actives in order to evaluate a possible synergy or additive effect. A cream/serum containing 5% argireline solution (0.05%) and 5% leuphasyl solution (0.05%) was applied twice daily around the eyes of 15 volunteers, aged 39 to 63, for 28 days. A decrease of 24.62% was accomplished, with maximum values up to –46.53%. Both peptides show additive effects due to their complementary mechanisms.

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.